Director, Duke Translational Medicine Institute
Vice Chancellor for Clinical and Translational Research
Vice Chancellor for Clinical and Translational Research
Department / Division
Medicine / Medicine - Cardiology
Medicine / Medicine - Cardiology
Address
DUMC 3701
Durham, NC 27710
200 Trent Drive, 1117 Davison Building
Durham, NC 27710
DUMC 3701
Durham, NC 27710
200 Trent Drive, 1117 Davison Building
Durham, NC 27710
Appointment Telephone
919-681-5816
919-681-5816
Office Telephone
919-668-8820
919-668-8820
Fax Telephone
919-668-7103
Training919-668-7103
- MD, Duke University School of Medicine, 1978
- Medicine, University of California–San Francisco Medical Center, 1979-1980
- Cardiology, Duke University Medical Center, 1980-1983
Clinical Interests
Chronic coronary artery disease, heart failure, acute coronary syndromes
Chronic coronary artery disease, heart failure, acute coronary syndromes
Research Interests
Robert Califf, MD, is the Donald F. Fortin, MD, Professor of Cardiology, Vice Chancellor for Clinical Research and Director of the Duke Translational Medicine Institute. He is also Professor of Medicine in the Division of Cardiology and remains a practicing cardiologist. Dr. Califf has led some of the best-known clinical trials and health outcomes studies in cardiovascular medicine and has published over 1,000 peer reviewed original articles in collaboration with his colleagues. He is currently the 7th most frequently cited author in the field of medicine globally according to the ISI. He is considered a leader in the fields of quality of care, technology development and health policy. He has served on numerous committees and panels assisting in the development of health policy including the Cardiorenal Panel of the FDA and multiple Institute of Medicine Committees, including the Committee on Identifying and Preventing Medication Errors, the Forum on Drug Discovery and Translation and the Science Board of the FDA. He was the founding Director of the Coordinating Center for the Centers for Education and Research in Therapeutics (CERTs), a public/private partnership focused on the safety of medical products. After 10 years as founding director of the DCRI he has founded the Duke Translational Medicine Institute, which encompasses the spectrum of translational research at Duke.
Industry Relationships and Collaborations (What's this?)Robert Califf, MD, is the Donald F. Fortin, MD, Professor of Cardiology, Vice Chancellor for Clinical Research and Director of the Duke Translational Medicine Institute. He is also Professor of Medicine in the Division of Cardiology and remains a practicing cardiologist. Dr. Califf has led some of the best-known clinical trials and health outcomes studies in cardiovascular medicine and has published over 1,000 peer reviewed original articles in collaboration with his colleagues. He is currently the 7th most frequently cited author in the field of medicine globally according to the ISI. He is considered a leader in the fields of quality of care, technology development and health policy. He has served on numerous committees and panels assisting in the development of health policy including the Cardiorenal Panel of the FDA and multiple Institute of Medicine Committees, including the Committee on Identifying and Preventing Medication Errors, the Forum on Drug Discovery and Translation and the Science Board of the FDA. He was the founding Director of the Coordinating Center for the Centers for Education and Research in Therapeutics (CERTs), a public/private partnership focused on the safety of medical products. After 10 years as founding director of the DCRI he has founded the Duke Translational Medicine Institute, which encompasses the spectrum of translational research at Duke.
This faculty member (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.
- Amilyn
- Aterovax
- Bayer
- Bristol Myers Squibb
- CV Sight
- Gambro
- Gilead Sciences, Inc.
- Hoffman LaRoche (Roche Holding)
- Kowa Research Institute, Inc.
- Merck
- N30 Pharma
- Nile Therapeutics
- Novartis
- Orexigen Therapeutics, Inc.
- Pfizer Inc.
- Portola
- Pozen
- Regeneron Pharmaceuticals
- Sankyo Co. (Daiichi Sankyo)/Eli Lilly
- Scios, Inc. (Johnson & Johnson)
- Servier INternational
Representative Publications
DeMets DL, Califf RM. A historical perspective on clinical trials innovation and leadership: where have the academics gone? JAMA. 2011 Feb 16;305(7):713-4. (2011) Abstract
Vamadevan AS, Shah BR, Califf RM, Prabhakaran D. Cardiovascular research in India: A perspective. Am Heart J. 2011 Mar;161(3):431-8. (2011) Abstract
Zarin DA, Tse T, Williams RJ, Califf RM, Ide NC. The ClinicalTrials.gov results database--update and key issues. N Engl J Med. 2011 Mar 3;364(9):852-60. (2011) Abstract
, Holman RR, Haffner SM, McMurray JJ, Bethel MA, Holzhauer B, Hua TA, Belenkov Y, Boolell M, Buse JB, Buckley BM, Chacra AR, Chiang FT, Charbonnel B, Chow CC, Davies MJ, Deedwania P, Diem P, Einhorn D, Fonseca V, Fulcher GR, Gaciong Z, Gaztambide S, Giles T, Horton E, Ilkova H, Jenssen T, Kahn SE, Krum H, Laakso M, Leiter LA, Levitt NS, Mareev V, Martinez F, Masson C, Mazzone T, Meaney E, Nesto R, Pan C, Prager R, Raptis SA, Rutten GE, Sandstroem H, Schaper F, Scheen A, Schmitz O, Sinay I, Soska V, Stender S, Tamás G, Tognoni G, Tuomilehto J, Villamil AS, Vozár J, Califf RM. Effect of nateglinide on the incidence of diabetes and cardiovascular events. N Engl J Med. 2010 Apr 22;362(16):1463-76. (2010) Abstract
, McMurray JJ, Holman RR, Haffner SM, Bethel MA, Holzhauer B, Hua TA, Belenkov Y, Boolell M, Buse JB, Buckley BM, Chacra AR, Chiang FT, Charbonnel B, Chow CC, Davies MJ, Deedwania P, Diem P, Einhorn D, Fonseca V, Fulcher GR, Gaciong Z, Gaztambide S, Giles T, Horton E, Ilkova H, Jenssen T, Kahn SE, Krum H, Laakso M, Leiter LA, Levitt NS, Mareev V, Martinez F, Masson C, Mazzone T, Meaney E, Nesto R, Pan C, Prager R, Raptis SA, Rutten GE, Sandstroem H, Schaper F, Scheen A, Schmitz O, Sinay I, Soska V, Stender S, Tamás G, Tognoni G, Tuomilehto J, Villamil AS, Vozár J, Califf RM. Effect of valsartan on the incidence of diabetes and cardiovascular events. N Engl J Med. 2010 Apr 22;362(16):1477-90. (2010) Abstract
Califf RM, Armstrong PW, Granger CB, Harrington RA, Lee K, Simes RJ, Van de Werf F, Wallentin L, White HD, . Towards a new order in cardiovascular medicine: re-engineering through global collaboration. Eur Heart J. 2010 Apr;31(8):911-7. (2010) Abstract
Califf RM, Berglund L, . Linking scientific discovery and better health for the nation: the first three years of the NIH's Clinical and Translational Science Awards. Acad Med. 2010 Mar;85(3):457-62. (2010) Abstract
Dzau VJ, Ackerly DC, Sutton-Wallace P, Merson MH, Williams RS, Krishnan KR, Taber RC, Califf RM. The role of academic health science systems in the transformation of medicine. Lancet. 2010 Mar 13;375(9718):949-53. (2010)Abstract
Harrington RA, Califf RM. There is a role for industry-sponsored education in cardiology. Circulation. 2010 May 25;121(20):2221-7. (2010) Abstract
Califf RM, . Key issues for global cardiovascular medicine. Lancet. 2009 Aug 15;374(9689):508-10. (2009) Abstract
Califf RM, Harrington RA, Blazing MA. Premature release of data from clinical trials of ezetimibe. N Engl J Med. 2009 Aug 13;361(7):712-7. (2009) Abstract
Califf RM. A virtuous cycle to improve hypertension outcomes at a national level: linking public health and individualized medicine. Hypertension. 2009 Feb;53(2):105-7. (2009) Abstract
Califf RM. Clinical research sites--the underappreciated component of the clinical research system. JAMA. 2009 Nov 11;302(18):2025-7. (2009) Abstract
Califf RM. Rational use of medications: if Canada can't do it ... CMAJ. 2009 Jul 7;181(1-2):15-6. (2009) Abstract
Coller BS, Califf RM. Traversing the valley of death: a guide to assessing prospects for translational success. Sci Transl Med. 2009 Dec 9;1(10):10cm9. (2009) Abstract
Al-Khatib SM, Sanders GD, Bigger JT, Buxton AE, Califf RM, Carlson M, Curtis A, Curtis J, Fain E, Gersh BJ, Gold MR, Haghighi-Mood A, Hammill SC, Healey J, Hlatky M, Hohnloser S, Kim RJ, Lee K, Mark D, Mianulli M, Mitchell B, Prystowsky EN, Smith J, Steinhaus D, Zareba W, . Preventing tomorrow's sudden cardiac death today: part I: Current data on risk stratification for sudden cardiac death. Am Heart J. 2007 Jun;153(6):941-50. (2007) Abstract
Al-Khatib SM, Shaw LK, O'Connor C, Kong M, Califf RM. Incidence and predictors of sudden cardiac death in patients with diastolic heart failure. J Cardiovasc Electrophysiol. 2007 Dec;18(12):1231-5. (2007) Abstract
Anderson JL, Adams CD, Antman EM, Bridges CR, Califf RM, Casey DE Jr, Chavey WE 2nd, Fesmire FM, Hochman JS, Levin TN, Lincoff AM, Peterson ED, Theroux P, Wenger NK, Wright RS, Smith SC Jr, Jacobs AK, Adams CD, Anderson JL, Antman EM, Halperin JL, Hunt SA, Krumholz HM, Kushner FG, Lytle BW, Nishimura R, Ornato JP, Page RL, Riegel B, , , , , , , . ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-Elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction) developed in collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine. J Am Coll Cardiol. 2007 Aug 14;50(7):e1-e157. (2007)Abstract
Anderson JL, Adams CD, Antman EM, Bridges CR, Califf RM, Casey DE Jr, Chavey WE 2nd, Fesmire FM, Hochman JS, Levin TN, Lincoff AM, Peterson ED, Theroux P, Wenger NK, Wright RS, Smith SC Jr, Jacobs AK, Halperin JL, Hunt SA, Krumholz HM, Kushner FG, Lytle BW, Nishimura R, Ornato JP, Page RL, Riegel B, , , , , , , . ACC/AHA 2007 guidelines for the management of patients with unstable angina/non ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non ST-Elevation Myocardial Infarction): developed in collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons: endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine. Circulation. 2007 Aug 14;116(7):e148-304. (2007) Abstract
Barbagelata A, Perna ER, Clemmensen P, Uretsky BF, Canella JP, Califf RM, Granger CB, Adams GL, Merla R, Birnbaum Y. Time to reperfusion in acute myocardial infarction. It is time to reduce it! J Electrocardiol. 2007 Jul;40(3):257-64. (2007)Abstract
Bennett-Guerrero E, Veldman TH, Doctor A, Telen MJ, Ortel TL, Reid TS, Mulherin MA, Zhu H, Buck RD, Califf RM, McMahon TJ. Evolution of adverse changes in stored RBCs. Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17063-8. (2007)Abstract
Califf RM, . Benefit assessment of therapeutic products: the Centers for Education and Research on Therapeutics. Pharmacoepidemiol Drug Saf. 2007 Jan;16(1):5-16. (2007) Abstract
Califf RM, Harrington RA, Madre LK, Peterson ED, Roth D, Schulman KA. Curbing the cardiovascular disease epidemic: aligning industry, government, payers, and academics. Health Aff (Millwood). 2007 Jan-Feb;26(1):62-74. (2007) Abstract
Califf RM, Mehta RH, Peterson ED. Clinical quality in non-ST-elevation acute coronary syndromes. Am J Med. 2007 Nov;120(11):930-5. (2007) Abstract
Echols MR, Mahaffey KW, Banerjee A, Pieper KS, Stebbins A, Lansky A, Cohen MG, Velazquez E, Santos R, Newby LK, Gurfinkel EP, Biasucci L, Ferguson JJ, Califf RM. Racial differences among high-risk patients presenting with non-ST-segment elevation acute coronary syndromes (results from the SYNERGY trial). Am J Cardiol. 2007 Feb 1;99(3):315-21. (2007) Abstract
Eisenstein EL, Anstrom KJ, Kong DF, Shaw LK, Tuttle RH, Mark DB, Kramer JM, Harrington RA, Matchar DB, Kandzari DE, Peterson ED, Schulman KA, Califf RM. Clopidogrel use and long-term clinical outcomes after drug-eluting stent implantation. JAMA. 2007 Jan 10;297(2):159-68. (2007) Abstract
Goyal A, Alexander JH, Hafley GE, Graham SH, Mehta RH, Mack MJ, Wolf RK, Cohn LH, Kouchoukos NT, Harrington RA, Gennevois D, Gibson CM, Califf RM, Ferguson TB Jr, Peterson ED, . Outcomes associated with the use of secondary prevention medications after coronary artery bypass graft surgery. Ann Thorac Surg. 2007 Mar;83(3):993-1001. (2007) Abstract
Hasselblad V, Gattis Stough W, Shah MR, Lokhnygina Y, O'Connor CM, Califf RM, Adams KF Jr. Relation between dose of loop diuretics and outcomes in a heart failure population: results of the ESCAPE trial. Eur J Heart Fail. 2007 Oct;9(10):1064-9. (2007) Abstract
Hernández AV, Westerhout CM, Steyerberg EW, Ioannidis JP, Bueno H, White H, Theroux P, Moliterno DJ, Armstrong PW, Califf RM, Wallentin LC, Simoons ML, Boersma E. Effects of platelet glycoprotein IIb/IIIa receptor blockers in non-ST segment elevation acute coronary syndromes: benefit and harm in different age subgroups. Heart. 2007 Apr;93(4):450-5. (2007) Abstract
Jiang W, Kuchibhatla M, Clary GL, Cuffe MS, Christopher EJ, Alexander JD, Califf RM, Krishnan RR, O'Connor CM. Relationship between depressive symptoms and long-term mortality in patients with heart failure. Am Heart J. 2007 Jul;154(1):102-8. (2007) Abstract
Li JS, Eisenstein EL, Grabowski HG, Reid ED, Mangum B, Schulman KA, Goldsmith JV, Murphy MD, Califf RM, Benjamin DK Jr. Economic return of clinical trials performed under the pediatric exclusivity program. JAMA. 2007 Feb 7;297(5):480-8. (2007) Abstract
Li JS, Yow E, Berezny KY, Rhodes JF, Bokesch PM, Charpie JR, Forbus GA, Mahony L, Boshkov L, Lambert V, Bonnet D, Michel-Behnke I, Graham TP, Takahashi M, Jaggers J, Califf RM, Rakhit A, Fontecave S, Sanders SP. Clinical outcomes of palliative surgery including a systemic-to-pulmonary artery shunt in infants with cyanotic congenital heart disease: does aspirin make a difference? Circulation. 2007 Jul 17;116(3):293-7. (2007) Abstract
Mahaffey KW, Roe MT, Kilaru R, Alexander JH, Van de Werf F, Califf RM, Simoons ML, Topol EJ, Harrington RA. Creatine kinase-MB elevation after coronary artery bypass grafting surgery in patients with non-ST-segment elevation acute coronary syndromes predict worse outcomes: results from four large clinical trials. Eur Heart J. 2007 Feb;28(4):425-32. (2007) Abstract
Mark DB, Van de Werf FJ, Simes RJ, White HD, Wallentin LC, Califf RM, Armstrong PW, . Cardiovascular disease on a global scale: defining the path forward for research and practice. Eur Heart J. 2007 Nov;28(21):2678-84. (2007) Abstract
Califf RM, Adams K, McKenna W, Gheorghiade M, Uretsky B, McNulty SE, Darius H, Schulman KA, Zannad F, Handberg-Thurmond E, Harrell Jr. FE, Wheeler W, Soler-Soler J, Swedburg K. A randomized controlled trial of epoprostenol therapy for severe congestive heart failure: the Flolan international randomized survival trial (FIRST). Am Heart J 1997;134:44-54. (191) (1997)
The BARI Investigators. The Bypass Angioplasty Revascularization Investigation (BARI): Five-year clinical and functional outcome comparing bypass surgery and angioplasty in patients with multivessel coronary disease: A multicenter randomized trial JAMA 1997;277:715-721. (354) (1997)
The EPILOG Investigators (Topol EJ, Califf RM, Lincoff AM, Tcheng JE, Cabot CF, Weisman HF, Kereiakes D, Lausten D, Runyon JP, Howard W, Kelly T, Muncy D, Timmis G, Safian M, Davey D, Kleiman NS, Rose D, Basinger L, Rouse C, Dramer J, Wilson R, Talley JD, Boyles M, Navetta FI, Lebeuf R, Kraft P, et al.) Platelet glycoprotein IIb/IIIa receptor blockade and low-dose heparin during percutaneous coronary revascularization. N Engl J Med 1997;336(24):1689-1696. (420) (1997)
The GUSTO III (The Global Use of Strategies to Open Occluded Coronary Arteries) Investigators (Eric J. Topol). A comparison of Reteplase with Alteplase for acute myocardial infarction. N Eng J Med 1997;337:1118-1123. (454) (1997)
The IMPACT II Investigators. (Tcheng JE, Lincoff AM, Sigmon KN, Lee KL, Kitt MM, Califf RM, Topol EJ, Juran N, Worley S. Tuzi J, Hollywood L, Kleiman NS, Ali MN, Rose D, Kereiakes DJ, Higby N, George J, Heibrunn S, Roncevich T, Burnheimer B, Ivanhoe R, Meade L, Rund M, Tannenaum M, Stangle D, et al.) Randomised placebo-controlled trial of effect of eptifibatide on complications of percutaneous coronary intervention - IMPACT II. Lancet 1997;349(9063):1422-1428. (371) (1997)
DeMets DL, Califf RM. A historical perspective on clinical trials innovation and leadership: where have the academics gone? JAMA. 2011 Feb 16;305(7):713-4. (2011) Abstract
Vamadevan AS, Shah BR, Califf RM, Prabhakaran D. Cardiovascular research in India: A perspective. Am Heart J. 2011 Mar;161(3):431-8. (2011) Abstract
Zarin DA, Tse T, Williams RJ, Califf RM, Ide NC. The ClinicalTrials.gov results database--update and key issues. N Engl J Med. 2011 Mar 3;364(9):852-60. (2011) Abstract
, Holman RR, Haffner SM, McMurray JJ, Bethel MA, Holzhauer B, Hua TA, Belenkov Y, Boolell M, Buse JB, Buckley BM, Chacra AR, Chiang FT, Charbonnel B, Chow CC, Davies MJ, Deedwania P, Diem P, Einhorn D, Fonseca V, Fulcher GR, Gaciong Z, Gaztambide S, Giles T, Horton E, Ilkova H, Jenssen T, Kahn SE, Krum H, Laakso M, Leiter LA, Levitt NS, Mareev V, Martinez F, Masson C, Mazzone T, Meaney E, Nesto R, Pan C, Prager R, Raptis SA, Rutten GE, Sandstroem H, Schaper F, Scheen A, Schmitz O, Sinay I, Soska V, Stender S, Tamás G, Tognoni G, Tuomilehto J, Villamil AS, Vozár J, Califf RM. Effect of nateglinide on the incidence of diabetes and cardiovascular events. N Engl J Med. 2010 Apr 22;362(16):1463-76. (2010) Abstract
, McMurray JJ, Holman RR, Haffner SM, Bethel MA, Holzhauer B, Hua TA, Belenkov Y, Boolell M, Buse JB, Buckley BM, Chacra AR, Chiang FT, Charbonnel B, Chow CC, Davies MJ, Deedwania P, Diem P, Einhorn D, Fonseca V, Fulcher GR, Gaciong Z, Gaztambide S, Giles T, Horton E, Ilkova H, Jenssen T, Kahn SE, Krum H, Laakso M, Leiter LA, Levitt NS, Mareev V, Martinez F, Masson C, Mazzone T, Meaney E, Nesto R, Pan C, Prager R, Raptis SA, Rutten GE, Sandstroem H, Schaper F, Scheen A, Schmitz O, Sinay I, Soska V, Stender S, Tamás G, Tognoni G, Tuomilehto J, Villamil AS, Vozár J, Califf RM. Effect of valsartan on the incidence of diabetes and cardiovascular events. N Engl J Med. 2010 Apr 22;362(16):1477-90. (2010) Abstract
Califf RM, Armstrong PW, Granger CB, Harrington RA, Lee K, Simes RJ, Van de Werf F, Wallentin L, White HD, . Towards a new order in cardiovascular medicine: re-engineering through global collaboration. Eur Heart J. 2010 Apr;31(8):911-7. (2010) Abstract
Califf RM, Berglund L, . Linking scientific discovery and better health for the nation: the first three years of the NIH's Clinical and Translational Science Awards. Acad Med. 2010 Mar;85(3):457-62. (2010) Abstract
Dzau VJ, Ackerly DC, Sutton-Wallace P, Merson MH, Williams RS, Krishnan KR, Taber RC, Califf RM. The role of academic health science systems in the transformation of medicine. Lancet. 2010 Mar 13;375(9718):949-53. (2010)Abstract
Harrington RA, Califf RM. There is a role for industry-sponsored education in cardiology. Circulation. 2010 May 25;121(20):2221-7. (2010) Abstract
Califf RM, . Key issues for global cardiovascular medicine. Lancet. 2009 Aug 15;374(9689):508-10. (2009) Abstract
Califf RM, Harrington RA, Blazing MA. Premature release of data from clinical trials of ezetimibe. N Engl J Med. 2009 Aug 13;361(7):712-7. (2009) Abstract
Califf RM. A virtuous cycle to improve hypertension outcomes at a national level: linking public health and individualized medicine. Hypertension. 2009 Feb;53(2):105-7. (2009) Abstract
Califf RM. Clinical research sites--the underappreciated component of the clinical research system. JAMA. 2009 Nov 11;302(18):2025-7. (2009) Abstract
Califf RM. Rational use of medications: if Canada can't do it ... CMAJ. 2009 Jul 7;181(1-2):15-6. (2009) Abstract
Coller BS, Califf RM. Traversing the valley of death: a guide to assessing prospects for translational success. Sci Transl Med. 2009 Dec 9;1(10):10cm9. (2009) Abstract
Al-Khatib SM, Sanders GD, Bigger JT, Buxton AE, Califf RM, Carlson M, Curtis A, Curtis J, Fain E, Gersh BJ, Gold MR, Haghighi-Mood A, Hammill SC, Healey J, Hlatky M, Hohnloser S, Kim RJ, Lee K, Mark D, Mianulli M, Mitchell B, Prystowsky EN, Smith J, Steinhaus D, Zareba W, . Preventing tomorrow's sudden cardiac death today: part I: Current data on risk stratification for sudden cardiac death. Am Heart J. 2007 Jun;153(6):941-50. (2007) Abstract
Al-Khatib SM, Shaw LK, O'Connor C, Kong M, Califf RM. Incidence and predictors of sudden cardiac death in patients with diastolic heart failure. J Cardiovasc Electrophysiol. 2007 Dec;18(12):1231-5. (2007) Abstract
Anderson JL, Adams CD, Antman EM, Bridges CR, Califf RM, Casey DE Jr, Chavey WE 2nd, Fesmire FM, Hochman JS, Levin TN, Lincoff AM, Peterson ED, Theroux P, Wenger NK, Wright RS, Smith SC Jr, Jacobs AK, Adams CD, Anderson JL, Antman EM, Halperin JL, Hunt SA, Krumholz HM, Kushner FG, Lytle BW, Nishimura R, Ornato JP, Page RL, Riegel B, , , , , , , . ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-Elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction) developed in collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine. J Am Coll Cardiol. 2007 Aug 14;50(7):e1-e157. (2007)Abstract
Anderson JL, Adams CD, Antman EM, Bridges CR, Califf RM, Casey DE Jr, Chavey WE 2nd, Fesmire FM, Hochman JS, Levin TN, Lincoff AM, Peterson ED, Theroux P, Wenger NK, Wright RS, Smith SC Jr, Jacobs AK, Halperin JL, Hunt SA, Krumholz HM, Kushner FG, Lytle BW, Nishimura R, Ornato JP, Page RL, Riegel B, , , , , , , . ACC/AHA 2007 guidelines for the management of patients with unstable angina/non ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non ST-Elevation Myocardial Infarction): developed in collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons: endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine. Circulation. 2007 Aug 14;116(7):e148-304. (2007) Abstract
Barbagelata A, Perna ER, Clemmensen P, Uretsky BF, Canella JP, Califf RM, Granger CB, Adams GL, Merla R, Birnbaum Y. Time to reperfusion in acute myocardial infarction. It is time to reduce it! J Electrocardiol. 2007 Jul;40(3):257-64. (2007)Abstract
Bennett-Guerrero E, Veldman TH, Doctor A, Telen MJ, Ortel TL, Reid TS, Mulherin MA, Zhu H, Buck RD, Califf RM, McMahon TJ. Evolution of adverse changes in stored RBCs. Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17063-8. (2007)Abstract
Califf RM, . Benefit assessment of therapeutic products: the Centers for Education and Research on Therapeutics. Pharmacoepidemiol Drug Saf. 2007 Jan;16(1):5-16. (2007) Abstract
Califf RM, Harrington RA, Madre LK, Peterson ED, Roth D, Schulman KA. Curbing the cardiovascular disease epidemic: aligning industry, government, payers, and academics. Health Aff (Millwood). 2007 Jan-Feb;26(1):62-74. (2007) Abstract
Califf RM, Mehta RH, Peterson ED. Clinical quality in non-ST-elevation acute coronary syndromes. Am J Med. 2007 Nov;120(11):930-5. (2007) Abstract
Echols MR, Mahaffey KW, Banerjee A, Pieper KS, Stebbins A, Lansky A, Cohen MG, Velazquez E, Santos R, Newby LK, Gurfinkel EP, Biasucci L, Ferguson JJ, Califf RM. Racial differences among high-risk patients presenting with non-ST-segment elevation acute coronary syndromes (results from the SYNERGY trial). Am J Cardiol. 2007 Feb 1;99(3):315-21. (2007) Abstract
Eisenstein EL, Anstrom KJ, Kong DF, Shaw LK, Tuttle RH, Mark DB, Kramer JM, Harrington RA, Matchar DB, Kandzari DE, Peterson ED, Schulman KA, Califf RM. Clopidogrel use and long-term clinical outcomes after drug-eluting stent implantation. JAMA. 2007 Jan 10;297(2):159-68. (2007) Abstract
Goyal A, Alexander JH, Hafley GE, Graham SH, Mehta RH, Mack MJ, Wolf RK, Cohn LH, Kouchoukos NT, Harrington RA, Gennevois D, Gibson CM, Califf RM, Ferguson TB Jr, Peterson ED, . Outcomes associated with the use of secondary prevention medications after coronary artery bypass graft surgery. Ann Thorac Surg. 2007 Mar;83(3):993-1001. (2007) Abstract
Hasselblad V, Gattis Stough W, Shah MR, Lokhnygina Y, O'Connor CM, Califf RM, Adams KF Jr. Relation between dose of loop diuretics and outcomes in a heart failure population: results of the ESCAPE trial. Eur J Heart Fail. 2007 Oct;9(10):1064-9. (2007) Abstract
Hernández AV, Westerhout CM, Steyerberg EW, Ioannidis JP, Bueno H, White H, Theroux P, Moliterno DJ, Armstrong PW, Califf RM, Wallentin LC, Simoons ML, Boersma E. Effects of platelet glycoprotein IIb/IIIa receptor blockers in non-ST segment elevation acute coronary syndromes: benefit and harm in different age subgroups. Heart. 2007 Apr;93(4):450-5. (2007) Abstract
Jiang W, Kuchibhatla M, Clary GL, Cuffe MS, Christopher EJ, Alexander JD, Califf RM, Krishnan RR, O'Connor CM. Relationship between depressive symptoms and long-term mortality in patients with heart failure. Am Heart J. 2007 Jul;154(1):102-8. (2007) Abstract
Li JS, Eisenstein EL, Grabowski HG, Reid ED, Mangum B, Schulman KA, Goldsmith JV, Murphy MD, Califf RM, Benjamin DK Jr. Economic return of clinical trials performed under the pediatric exclusivity program. JAMA. 2007 Feb 7;297(5):480-8. (2007) Abstract
Li JS, Yow E, Berezny KY, Rhodes JF, Bokesch PM, Charpie JR, Forbus GA, Mahony L, Boshkov L, Lambert V, Bonnet D, Michel-Behnke I, Graham TP, Takahashi M, Jaggers J, Califf RM, Rakhit A, Fontecave S, Sanders SP. Clinical outcomes of palliative surgery including a systemic-to-pulmonary artery shunt in infants with cyanotic congenital heart disease: does aspirin make a difference? Circulation. 2007 Jul 17;116(3):293-7. (2007) Abstract
Mahaffey KW, Roe MT, Kilaru R, Alexander JH, Van de Werf F, Califf RM, Simoons ML, Topol EJ, Harrington RA. Creatine kinase-MB elevation after coronary artery bypass grafting surgery in patients with non-ST-segment elevation acute coronary syndromes predict worse outcomes: results from four large clinical trials. Eur Heart J. 2007 Feb;28(4):425-32. (2007) Abstract
Mark DB, Van de Werf FJ, Simes RJ, White HD, Wallentin LC, Califf RM, Armstrong PW, . Cardiovascular disease on a global scale: defining the path forward for research and practice. Eur Heart J. 2007 Nov;28(21):2678-84. (2007) Abstract
Califf RM, Adams K, McKenna W, Gheorghiade M, Uretsky B, McNulty SE, Darius H, Schulman KA, Zannad F, Handberg-Thurmond E, Harrell Jr. FE, Wheeler W, Soler-Soler J, Swedburg K. A randomized controlled trial of epoprostenol therapy for severe congestive heart failure: the Flolan international randomized survival trial (FIRST). Am Heart J 1997;134:44-54. (191) (1997)
The BARI Investigators. The Bypass Angioplasty Revascularization Investigation (BARI): Five-year clinical and functional outcome comparing bypass surgery and angioplasty in patients with multivessel coronary disease: A multicenter randomized trial JAMA 1997;277:715-721. (354) (1997)
The EPILOG Investigators (Topol EJ, Califf RM, Lincoff AM, Tcheng JE, Cabot CF, Weisman HF, Kereiakes D, Lausten D, Runyon JP, Howard W, Kelly T, Muncy D, Timmis G, Safian M, Davey D, Kleiman NS, Rose D, Basinger L, Rouse C, Dramer J, Wilson R, Talley JD, Boyles M, Navetta FI, Lebeuf R, Kraft P, et al.) Platelet glycoprotein IIb/IIIa receptor blockade and low-dose heparin during percutaneous coronary revascularization. N Engl J Med 1997;336(24):1689-1696. (420) (1997)
The GUSTO III (The Global Use of Strategies to Open Occluded Coronary Arteries) Investigators (Eric J. Topol). A comparison of Reteplase with Alteplase for acute myocardial infarction. N Eng J Med 1997;337:1118-1123. (454) (1997)
The IMPACT II Investigators. (Tcheng JE, Lincoff AM, Sigmon KN, Lee KL, Kitt MM, Califf RM, Topol EJ, Juran N, Worley S. Tuzi J, Hollywood L, Kleiman NS, Ali MN, Rose D, Kereiakes DJ, Higby N, George J, Heibrunn S, Roncevich T, Burnheimer B, Ivanhoe R, Meade L, Rund M, Tannenaum M, Stangle D, et al.) Randomised placebo-controlled trial of effect of eptifibatide on complications of percutaneous coronary intervention - IMPACT II. Lancet 1997;349(9063):1422-1428. (371) (1997)
Topol EJ, Califf RM, Van de Werf F, Simoons M, Hampton J, Lee KL, White H, Simes J, Armstrong PW, for the Virtual Coordinating Center for Global Collaborative Cardiovascular Research (VIGOUR) Group. Perspective on large-scale cardiovascular clinical trials in the new millennium. Circulation 1997;95:1072-1082 (337) (1997)
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